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Abstract
Purpose:The aim of the present study was
to evaluate the efficacy of the sequential
therapy consisted of multimodality in unresectable
non-small-cell lung cancer(NSCLC).
Patients and Methods:Eight-five patients
with NSCLC were those who had progressed
or relapsed after therapy with routine chemotherapy
or/and radiotherapy,and were not given operation
due to tumor factor or refused operation.The
therapy was consisted of transarterial chemotherapy
targeted to tumor vessels in lung,cryoablation
with Endocare System (Endocare,Irvine,CA,USA),photodynamic
therapy with Photofrin or Photosan as photosensetizer
for obstructive cancer in intratrachea or
intrabronchea,radiotherapy for patients
without previous same therapy,immunotherapy
with cytokine-induced killer cells or dendritic
cells(DC),and traditional Chinese medicine,that
were used in sequence.
Results:Seventy-four patients were entered
onto the perspective study with follow-up
duration of 6-21 months.Responses included
CR(complete response) in 21 cases(28.4%),PR(partial
response),31cases(41.9%),MR(minor response),8
cases(10.8%),NC(no change),9 cases(12.2%),and
PD (progressive disease),in 5 cases(6.7%).The
pain in patients of 51.2 percent (21/41)
had complete remmision and in 39.0%(16/41)
had partial remmision.75.7percent(36/74)
of patients had increased body weight,and
10.8 percent had stable body weight.85.7
percent(48 cases) of 56 patients were recieved
evaluation of performance status had increased
Karnovsky score.Among 74 cases,66 cases(81.1%)
were alive up to now with the 1-year survival
rate of 76.2 percent. |
病例
